Optimal Campaign in Leptospirosis Epidemic by Multiple Control Variables

• 作者: Gul Zaman Muhammad Altaf Khan Muhammad Ikhlaq Chohan Saeed Islam
• 来源期刊: 应用数学(英文)
• 学科: 数学
• 关键词: Mathematical Model OPTIMAL Control Pontryagin’s MAXIMUM PRINCIPLE Numerical Results
• 年，卷（期）: 2012,（11）
• 页码范围: 1655-1663
• 页数: 9页
• 分类号: O1

摘要

In this paper, we consider a leptospirosis epidemic model to implement optimal campaign by using multiple control variables. First, we show the existence of the control problem. Then we derive the conditions under which it is optimal to eradicate the leptospirosis infection and examine the impact of a possible educatioal/vaccinaction campaign using Pontryagin’s Maximum Principle. We completely characterize the optimal control problem and compute the numerical solution of the optimality system using an iterative method. The results obtained from the numerical simulations of the model show that a possible educational/vaccinaction combined with effective treatment regime would reduce the spread of the leptospirosis infection appreciably.