Synthesis and Crystal Structure of 2,3,4,6-tetra-O-Acetyl-1-{4-chloro-3-[1-（4-ethoxyphenyl）-1-methylethyl]phenyl}-1-deoxy-β-D-glucopyranose

• 作者: 刘巍 史永恒 汤立达 王玉丽 赵桂龙 邵华
• 来源期刊: 结构化学
• 学科: 其他
• 关键词: synthesis,crystal structure,C-glucoside,SGLT2 inhibitor,gem-dimethyl
• 年，卷（期）: 2012,（5）
• 页码范围: 690-694
• 页数: 5页
• 分类号: O
• 语种: 英文

摘要

The title compound was synthesized and its crystal structure was determined by single-crystal X-ray diffraction.The crystal is of monoclinic system（C31H37ClO10,Mr = 605.06）,space group P21 with a = 11.882（5）,b = 10.106（5）,c = 13.816（6）,V = 1545.9（12）（A°）^3,Z = 2,Dc = 1.300 g/cm^3,F（000） = 640,μ = 0.179 mm^-1,the final R = 0.0430 and wR = 0.0595 for 4960 observed reflections（I 〉 2σ（I））.The title compound was confirmed to be a β-anomer by single-crystal X-ray diffraction and 1H NMR.The proximal benzene ring is nearly orthogonal to the glucopyranoside ring,and the two benzene rings are also almost orthogonal to each other.Four non-classical intermolecular hydrogen bonds observed in the crystal lattice help to stabilize the crystal.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	汤立达		91	660	13.0	22.0
2	刘巍		30	114	6.0	9.0
3	赵桂龙		19	46	3.0	6.0
4	王玉丽		31	276	11.0	16.0
5	邵华		6	33	3.0	5.0
6	史永恒		2	0	0.0	0.0