Aluminum chloride:A highly efficient catalyst for addition of amines to carbodiimides to synthesize substituted guanidines

• 来源期刊: 科学通报(英文版)
• 学科: 化学
• 年，卷（期）: 2012,（26）
• 页码范围: 3419-3422
• 页数: 4页
• 分类号: O621.36
• 语种: 中文

摘要

A catalytic addition of amine N H bonds to carbodiimides using aluminum chloride as a Lewis acid catalyst is developed.The reaction proceeds under mild conditions without solvent to afford a series of substituted guanidines in good to excellent yields using a wide range of amines as substrates.Evidence of the proposed mechanism is provided by in situ infrared spectroscopy.