Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior

• 来源期刊: 科学通报(英文版)
• 学科: 医学
• 年，卷（期）: 2012,（27）
• 页码范围: 3631-3638
• 页数: 8页
• 分类号: R943
• 语种: 中文

摘要

Silica nanorattle with hollow and mesoporous structure has been proven to be an excellent drug carrier.However,how to control the drug release from silica nanorattle is still a challenge.In this study,we designed two methods,in-situ polymerization method and water in oil in water(W/O/W) double emulsion method,to coat a nanosized poly(lactic-co-glycolic acid)(PLGA) layer onto the surface of silica nanorattle for controlling the drug release behavior.Hydrophobic antitumor drug docetaxel was loaded into the PLGA coated silica nanorattle(PLGA@SN).The drug release profile,cellular uptake and cytotoxicity on human liver cancer HepG2 cells were evaluated to prove that the PLGA layer plays an effective role in tuning the drug delivery.