基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
Although there are several computational models that explain the trajectory that cells take during migration,till now little attention has been paid to the integration of the cell migration in a multi-signaling system.With that aim,a generalized model of cell migration and cell-cell interaction under multisignal environments is presented herein.In this work we investigate the spatio-temporal cell-cell interaction problem induced by mechano-chemo-thermotactic cues.It is assumed that formation of a new focal adhesion generates traction forces proportional to the stresses transmitted by the cell to the extracellular matrix.The cell velocity and polarization direction are calculated based on the equilibrium of the effective forces associated to cell motility.It is also assumed that,in addition to mechanotaxis signals,chemotactic and thermotactic cues control the direction of the resultant traction force.This model enables predicting the trajectory of migrating cells as well as the spatial and temporal distributions of the net traction force and cell velocity.Results indicate that the tendency of the cells is firstly to reach each other and then migrate towards an imaginary equilibrium plane located near the source of the signal.The position of this plane is sensitive to the gradient slope and the corresponding efficient factors.The cells come into contact and separate several times during migration.Adding other cues to the substrate(such as chemotaxis and/or thermotaxis)delays that primary contact.Moreover,in all states,the average local velocity and the net traction force of the cells decrease while the cells approach the cues source.Our findings are qualitatively consistent with experimental observations reported in the related literature.
推荐文章
肿瘤炎症微环境对小鼠结肠癌cell-in-cell的影响研究
结肠癌
炎症微环境
白介素6
肿瘤坏死因子
细胞进入
淋巴细胞-肿瘤细胞形成cell-in-cell胞内嵌合结构的特征及意义
cell-in-cell胞内嵌合结构
PLC/PRF/5细胞
PBMC
流式分选
克隆形成
采用Flat_Cell技术的ROM设计和分析
Flat_Cell
Flat_Cell Array
ROM
放大器
基于4G Small Cell的商场无线智能导购系统设计
移动通信网
SmallCell
本地IP接入
商场智能导购
内容精准推送
目标点智能导引
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 Cell Migration and Cell-Cell Interaction in the Presence of Mechano-Chemo-Thermotaxis
来源期刊 分子与细胞生物力学(英文) 学科 医学
关键词 CELL MIGRATION cell-cell interaction mechanotaxis CHEMOTAXIS thermotaxis numerical simulation FINITE element method
年,卷(期) 2013,(1) 所属期刊栏目
研究方向 页码范围 1-25
页数 25页 分类号 R73
字数 语种
DOI
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (0)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2013(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
研究主题发展历程
节点文献
CELL
MIGRATION
cell-cell
interaction
mechanotaxis
CHEMOTAXIS
thermotaxis
numerical
simulation
FINITE
element
method
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
分子与细胞生物力学(英文)
季刊
1556-5297
江苏省南京市浦口区东大路2号东大科技园A
出版文献量(篇)
27
总下载数(次)
0
总被引数(次)
0
论文1v1指导