Pharmacogenomics in oral diseases

• 作者: Gokul Sapna Sridharan Gokul
• 来源期刊: 世界口腔医学杂志
• 学科: 医学
• 关键词: PHARMACOGENOMICS ORAL Cancer PERIODONTAL diseases GENOMIC VARIATIONS TARGETED drug therapy
• 年，卷（期）: 2013,（4）
• 页码范围: 67-70
• 页数: 4页
• 分类号: R

摘要

The availability of newer technologies for identification and characterization of the human genome has enabled our understanding of the genetic variations in a majority of human diseases.Human genomic sequence varies in less than 1%among the different population group and these differences known as gene polymorphisms are the primary reasons for differences in individuals’response to various drug therapy.Also understanding the genetic changes may enable implementation of targeted therapy,thus providing for effective treatment strategies and minimizing the adverse side effects.Pharmacogenomics is a recent development in the field of personalized medicine which focuses on the genetic determinants of drug response at the levels of entire human genome.It primarily deals with tailoring of drug therapy for every individual based on their genetic make-up and identifying new target in various diseases for drug therapy.While the application of pharmacogenomics in systemic illness is well researched,its role in oral diseases needs documentation.Identifying specific targets in periodontitis,head and neck cancer,infections and genetic disorders can be beneficial in discovery of new drugs.This editorial provides an overview of basics of pharmacogenomics,its current role in disease management and its potential role in various head and neck diseases.