Challenges on Induction of Broadly Neutralizing Antibodies for Optimization of HIV Vaccines Development and Vectored Immunoprophylaxis

• 作者: Pankaj Kumar
• 来源期刊: 基于免疫的治疗疫苗和抗菌期刊(英文)
• 学科: 医学
• 关键词: HIV AIDS Broadly NEUTRALIZING ANTIBODIES (bNAbs) Vectored IMMUNOPROPHYLAXIS
• 年，卷（期）: 2013,（1）
• 页码范围: 9-13
• 页数: 5页
• 分类号: R5

摘要

Despite extensive research efforts, a preventive human immunodeficiency virus (HIV) vaccine remains one of the major challenges in the field of AIDS research. Experimental strategies which have been proven successful for other viral vaccines are not enough to tackle HIV-1 and new approaches to design effective preventive AIDS vaccines are of utmost importance. Due to enormous diversity among global circulating HIV strains, an effective HIV vaccine must elicit broadly protective antibodies based responses;therefore discovering new broadly neutralizing antibodies (bNAbs) against HIV has become major focus in HIV vaccine research. However further understanding of the viral targets of such antibodies and mechanisms of action of bNAbs is required for advancement of HIV vaccine research. This technical note discusses our current knowledge on the bNAbs and immunoprophylaxis using viral vectors with their relevance in designing of new candidates to HIV-1 vaccines.