Nanorobot Drug Delivery System for Curcumin for Enhanced Bioavailability during Treatment of Alzheimer’s Disease

• 作者: Kal Renganathan Sharma
• 来源期刊: 封装与吸附期刊(英文)
• 学科: 医学
• 关键词: Nanorobot Alzheimer’s Disease CURCUMA Longa Photodynamic Therapy INTRATHECAL Infusion Denbigh Reaction Scheme
• 年，卷（期）: 2013,（1）
• 页码范围: 24-34
• 页数: 11页
• 分类号: R73

摘要

Robotics has emerged as a collegiate course about 20 years ago at Stanford University, Stanford, CA. From the first IRB6, the electrically powered robot in 1974, the industry has grown over a 30-year period. A leading supplier of robots has put out over 100,000 robots by year 2001. Robot capable of handling 500 kg load was introduced in 2001, IRB 7000. A number of advances have been made in nanostructuring. About 40 different nanostructuring methods were reviewed recently [1]. Nanobots can be developed that effect cures of disorders that are difficult to treat. Principles from photodynamic therapy, fullerene chemistry, nanostructuring, X-rays, computers, pharmacokinetics and robotics are applied in a design of nanorobot for treatment of Alzheimer’s disease. The curcuma longa that has shown curative effects in rats’ brain with Alzheimer’s is complexed with fullerenes. The drug is inactive when caged. It is infused intrathecally into the cerebrospinal system. Irradiation of the hypothalamous and other areas of the brain where Alzheimer’s disease is prevalent lead to breakage of fullerenes and availability of the drug with the diseased cells. Due to better mass transfer, better cure is affected. The other plausible reactions such as addition polymerization of fullerene, polycurcumin formation and other hydrolysis reactions are modeled along with the drug action under the Denbigh scheme of reactions. The fractional yield of drug-curcumin interaction is a function of intensity of radiation, frequency of radiation, patient demographics, age, gender, and other disorders etc. Chromophore in curcumin is used as a sensor and computer imaging and feedback control design can result in more bioavailability for curcumin therapeutic action to cure Alzheimer’s disease. This study examines the principles used in the design, the strategy of the design of the nanorobot drug delivery system with a specific target and pharamacokinetic formulation of the associated competing parallel reactions. The burrow and link capabiliti