Bone-marrow derived cells participate in extramedullary hematopoiesis in a model of acetaminophen-induced acute liver failure in rats

• 作者: Fabiana Mayer Guilherme Baldo Luise Meurer Maria Cristina Belardinelli Mónica López Roberto Giugliani Talita Giacomet de Carvalho Ursula Matte
• 来源期刊: 干细胞探索(英文)
• 学科: 医学
• 关键词: EXTRAMEDULLARY HEMATOPOIESIS Bone MARROW Cells Acute Liver Failure ACETAMINOPHEN
• 年，卷（期）: 2013,（1）
• 页码范围: 44-46
• 页数: 3页
• 分类号: R73

摘要

Adult derived mononuclear bone marrow cells are a good alternative as cell therapy. These cells are capable of significantly improve survival rate of Wistar rats with acetaminophen (APAP) induced acute liver failure in ten days. However, long term of cell therapy is not deeply studied in the literature. Here, we report an extramedullary hematopoiesis process derived from transplanted mononuclear bone marrow cells in the liver of rats 10 days after APAP injection. This result indicates that liver maintains an adequate microenvironment for the occurrence of extramedullary hematopoiesis process. The consequence of this finding deserves more studies.