α-Galactosyl Phytosphingosine 2,6’-Diamide as an Inducer of Invariant Natural Killer T Cell

• 作者: Chun-Nan Yeh Chung-Shan Yu Ho-Lien Huang Kun-I Lin Shu-Fan Tien Wei-Ting Chen Ying-Cheng Huang
• 来源期刊: 药物化学期刊(英文)
• 学科: 医学
• 关键词: PHYTOSPHINGOSINE HPLC KETO Flow CYTOMETRY Simulation
• 年，卷（期）: 2013,（3）
• 页码范围: 55-59
• 页数: 5页
• 分类号: R73

摘要

Four a-galactosyl phytosphingosine 2,6’-diamide analogs were prepared from 2,6’-diamino a-galactosylphytosphingosine and the aromatic-bearing carboxylic acids. After purification with High Performance Liquid Chromatography, a flowcytometry for the four compounds for stimulation of human Va24+/Vb11+ NKT cell populations was carried out. Additional keto groups on the acyl chains of the 2,6’-diamide compound was associated with the enhanced stimulating effect.