We report the outcome of a pregnant woman with a life-threatening acute respiratory distress syndrome from a novel influenza A(H1N1)virus infection 3 d postpartum successfully managed by veno-arterial extracorporeal membrane oxygenation.The patient was successfully weaned from extracorporeal membrane oxygenation(ECMO)on day 10.Novel H1N1 virus infection was identified by real-time reverse transcriptionpolymerase chain reaction.Veno-arterial ECMO in this patient carried a number of specific advantages namely maintaining haemodynamic stability obviating the need for inotrope support and improving oxygenation compared to alternative approaches such as veno-venous ECMO and pumpless devices.Femoral arterial and venous cannulae were inserted in a pure percutaneous method allowing rapid establishment of extracorporeal circulation.Given the high mortality of acute respiratory distress syndrome following novel H1N1 virus infection,we advocate the use of ECMO when conventional mechanical ventilation fails.