Mechanotransduction in bone:Intervening in health and disease

• 作者: Anastasia Spyropoulou Efthimia K Basdra
• 来源期刊: 世界实验医学杂志
• 学科: 医学
• 关键词: MECHANOTRANSDUCTION BONE REMODELING BONE DISEASE BONE HEALTH
• 年，卷（期）: 2013,（4）
• 页码范围: 74-86
• 页数: 13页
• 分类号: R

摘要

Mechanotransduction has been proven to be one of the most significant variables in bone remodeling and its alterations have been shown to result in a variety of bone diseases.Osteoporosis,Paget’s disease,orthopedic disorders,osteopetrosis as well as hyperparathyroidism and hyperthyroidism all comprise conditions which have been linked with deregulated bone remodeling.Although the significance of mechanotransduction for bone health and disease is unquestionable,the mechanisms behind this important process have not been fully understood.This review will discuss the molecules that have been found to be implicated in mechanotransduction,as well as the mechanisms underlying bone health and disease,emphasizing on what is already known as well as new molecules potentially taking part in conveying mechanical signals from the cell surface towards the nucleus under physiological or pathologic conditions.It will also focus on the model systems currently used in mechanotransduction studies,like osteoblast-like cells as well as three-dimensional constructs and their applications among others.It will also examine the role of mechanostimulatory techniques in preventing and treating bone degenerative diseases and consider their applications in osteoporosis,craniofacial development,skeletal deregulations,fracture treatment,neurologic injuries following stroke or spinal cord injury,dentistry,hearing problems and bone implant integration in the near future.