Induction of microRNA resistance and secretion in differentiating human endometrial stromal cells

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2013,（1）
• 页码范围: 67-70
• 页数: 4页
• 语种: 英文
• DOI: 10.1093/jmcb/mjs058

摘要

Dear Editor, A key event in the preparation for pregnancy is the differentiation of human endometrial stromal cells (hESCs) into epithelioid decidual cells.This process,termed decidualization,is initiated in the stromal cells of the superficial endometrial layer ～9 days after ovulation.Upon decidualization,hESCs acquire the ability to resist oxidative stress,to modulate immune responses to fetal alloantigens,and to control trophoblast invasion.Differentiating primary hESCs recapitulate many changes in gene expression observed upon decidualization in vivo with progesterone and cAMP signaling pathways cooperating in hESCs at several levels [see review (Gellersen and Brosens,2003)].