6-Azido-Galactosyl Imidate as a Building Block for Preparation of 1-(4-Aminobutyl)-, Di-, Tri- and Tetra-Saccharides

• 作者: Cheng-Tse Pan Chung-Shan Yu Ho-Lien Huang Kun-I Lin Li-Wu Chiang Shui-Tein Chen Ying-Cheng Huang Yuan-Hsiao Su
• 来源期刊: 药物化学期刊(英文)
• 学科: 化学
• 关键词: GLYCOSYLATION CHEMOSELECTIVE IMIDATE Building Block Lactoside
• 年，卷（期）: 2013,（3）
• 页码范围: 74-86
• 页数: 13页
• 分类号: O6

摘要

6-azidogalactosyl imidate has been used as a donor to generate 1-(4-aminobutyl)-6-aminogalactose, 6-aminothiotolyl- glycosides of disaccharide, trisaccharide and tetrasaccharide that incorporates 6-azido group and 1-(4-tolyl)thio group. Trisaccharide and tetrasaccharide were obtained from lactosyl-based acceptor. The anomeric 1-(4-tolyl)thio group could be used to conjugate with sphingosine analogs to provide the alpha-Gal Sph analogs for library extension from the azido group.