EGFR mutation identifies distant squamous cell carcinoma as metastasis from lung adenocarcinoma

• 作者: Akira Tadokoro Asako Kunitomo Hiroaki Dobashi Naoki Watanabe Nobuhiro Kanaji Osamu Imataki Reiji Haba Shuji Bandoh Takayuki Takahama Takuya Matsunaga Tomoya Ishii Toshitetsu Hayashi
• 来源期刊: 世界呼吸病学杂志
• 学科: 医学
• 关键词: NON-SMALL CELL lung cancer Adenocarcinoma SQUAMOUS CELL carcinoma EPIDERMAL growth factor receptor mutation G719 METASTASIS
• 年，卷（期）: 2013,（2）
• 页码范围: 38-43
• 页数: 6页
• 分类号: R

摘要

Lung cancer metastasis is typically determined by histologic similarity between distant and primary lesions.Herein,we present a 70-year-old Japanese woman with an adenocarcinoma in her lung and a squamous cell carcinoma in her femur;both tumors had an identical epidermal growth factor receptor mutation,G719S.This indicated that both tumors had a common origin,despite their histologic dissimilarity.The tumor in the femur was thus identified genetically as a lung cancer metastasis.This case suggests that genetic analysis can determine whether a distant lesion is a lung cancer metastasis,particularly when the histology differs from that of the primary lesion.