Application of Optical Methods in Blood Studies upon Evaluation of Severity Rate of Diffuse Liver Pathology

• 作者: Abdrey Gromov Margarita Kruchinina Mikhail Voevoda Sergey Peltek Sergey Rykhlitsky Svetlana Kurilovich Vladimir Generalov Vladimir Kruchinin Vladimir Volodin
• 来源期刊: 分析科学方法和仪器期刊(英文)
• 学科: 医学
• 关键词: Optical Methods Blood Serum STUDIES Erythrocytes DIFFUSE Liver Disease Degree of FIBROSIS Dielectrophoresis ELLIPSOMETRY Raman SPECTROSCOPY IR Fourier SPECTROSCOPY
• 年，卷（期）: 2013,（2）
• 页码范围: 115-123
• 页数: 9页
• 分类号: R5

摘要

Possible early diagnostic application of optical methods (dielectrophoresis, spectral and imaging ellipsometry, Fourier-transform infrared spectroscopy, Raman spectroscopy) in studies of red blood cells and serum of patients with diffuse liver disease with varying degrees of fibrosis has been evaluated. Application of combined optical methods was confirmed to significantly improve the performance of sensitivity, specificity, and accuracy index as well as to achieve the reliable results in diagnosis of both severe fibrosis and slight ulterior liver fibrosis. Identified diagnostic potential of optical methods can be effectively utilized in noninvasive screening evaluation of stages of diffuse liver disease of various geneses.