Effect of Calcium and Strontium on Mesoporous Titania Coatings for Implant Applications

• 作者: H?kan Engqvist Kathryn Grandfield Marjam Ott Shiuli Pujari Wei Xia
• 来源期刊: 生物材料与纳米技术(英文)
• 学科: 医学
• 关键词: MESOPOROUS TITANIA CALCIUM STRONTIUM Drug Delivery BONE EISA
• 年，卷（期）: 2013,（2）
• 页码范围: 107-113
• 页数: 7页
• 分类号: R73

摘要

Increasing interest in the role of ions such as calcium and strontium in bone formation has called for the investigation of multifunctional ion-doped implant coatings. Mesoporous titania coatings incorporating calcium or strontium enabled a unique pore morphology and potential for drug delivery. Coatings were produced on titanium by an evaporation induced self-assembly method with the addition of calcium or strontium to the sol causing a shift in morphology from a hexagonally-packed to a worm-like porous network. Pore sizes ranged from 3.8 - 5 nm and coatings exhibited high surface areas between 181 - 215.5 m2/g, as measured by N2 adsorption-desorption. Coatings were loaded with 1 mg/ml Cephalothin, and showed sustained release of the antibiotic over one week in vitro. Cell studies confirmed that the ion addition had no toxic effect on human-like osteoblastic SaOS-2 cells. The results of this study suggest the potential for mesoporous coatings with calcium or strontium incorporation for direct bone-interfacing and combined drug delivery implant applications.