Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives

• 作者: Dongping Shao Fei Xue Reyila Wubulikasimu Rongmei Gao Weidong Ye Xianjin Luo Yanbing Yang Yuhuan Li
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: 1 2 4-Triazole Anti-Enterovirus COXSACKIE B Viruses
• 年，卷（期）: 2013,（1）
• 页码范围: 41-46
• 页数: 6页
• 分类号: O6

摘要

A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent activity, with a high antiviral potency (IC50 = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new synthesized compounds were confirmed by 1H-NMR spectra, mass spectra and elemental analyses.