Effects of human immunodeficiency virus on the erythrocyte and megakaryocyte lineages

• 作者: Alberto Clò Anna Miserocchi Cristina Ponti Davide Gibellini Maria Carla Re Silvia Morini
• 来源期刊: 世界病毒学杂志
• 学科: 医学
• 关键词: Human immunodeficiency virus Erythrocytes MEGAKARYOCYTES Haematopoietic PROGENITOR cells VIROLOGY
• 年，卷（期）: 2013,（2）
• 页码范围: 91-101
• 页数: 11页
• 分类号: R

摘要

Anaemia and thrombocytopenia are haematological disorders that can be detected in many human immunodeficiency virus(HIV)-positive patients during the development of HIV infection.The progressive decline of erythrocytes and platelets plays an important role both in HIV disease progression and in the clinical and therapeutic management of HIV-positive patients.HIV-dependent impairment of the megakaryocyte and erythrocyte lineages is multifactorial and particularly affects survival,proliferation and differentiation of bone marrow(BM)CD34+haematopoietic progenitor cells,the activity of BM stromal cells and the regulation of cytokine networks.In this review,we analyse the major HIV-related mechanisms that are involved in the genesis and development of the anaemia and thrombocytopenia observed in HIV positive patients.