为变形食道的有鳞的房间癌症的指向的治疗

• 作者: Antonia Digklia Ioannis A Voutsadakis
• 来源期刊: 世界胃肠肿瘤学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Esophageal carcinoma Squamous Targeted therapies Clinical trials EPIDERMAL GROWTH FACTOR RECEPTOR Vascular endothelial GROWTH FACTOR RECEPTOR MAMMALIAN target of RAPAMYCIN
• 年，卷（期）: 2013,（5）
• 页码范围: 88-96
• 页数: 9页
• 分类号: R735.1

摘要

Squamous cell carcinoma, one of the two major subtypes of esophageal carcinomas, constitutes the great majority of tumors in the upper and middle third of the organ. Declining in incidence in western countries, it continues to be a significant public health problem in the far east. Targeted treatments are novel therapies introduced in the clinical therapeutic armamentarium of oncology in the last 10-15 years. They represent a rational way of treating various cancers based on their molecular lesions. Although no such agent has been approved so far for the treatment of esophageal squamous cell carcinomas (ESCC), several are in clinical trials and several others have displayed pre-clinical activity that would justify the efforts and risks of pursuing their clinical development in this disease. This paper discusses some of these targeted agents in more advanced development in metastatic ESCC, as well as some promising drugs with pre-clinical or initial clinical data in the disease.