Aqueous-Phase, Palladium-Catalyzed Suzuki Reactions under Mild Conditions

• 作者: Gonghua Song Jiawei Zhang Yueqin Cai Zhongyuan Wu
• 来源期刊: 绿色与可持续化学(英文)
• 学科: 化学
• 关键词: SUZUKI Reaction Ionic Liquid-Supported DIOLS PHOSPHINE-FREE Ligands
• 年，卷（期）: 2013,（4）
• 页码范围: 1-5
• 页数: 5页
• 分类号: O6

摘要

Water-soluble ionic liquid-supported diols have been used as phosphine-free ligands in Suzuki couplings of aryl idides/bromides/chlorides under mild conditions in aqueous solvent. It was found that 2,2-bis((1-hexylimidazolium)-mehyl) propane-1,3-diol hexafluorophosphate (4) in combination with palladium (II) salts gave the most significant catalyst. Suzuki couplings of aryl iodides/bromides occurred efficiently at room temperature in water/acetonitrile. Notably, the reactions of hydrophilic aryl bromides gave high yields in neat water. The catalyst PdCl2-4 was recycled five times in Suzuki couplings in water before catalyst activity began to significantly drop. The average yield of five cycles was >95% per cycle.