Insights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2013,（3）
• 页码范围: 204-206
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/jmcb/mjs061

摘要

Dear Editor, Translesion synthesis (TLS) allows the DNA replication machinery to bypass an unrepaired DNA damage site using special polymerases called TLS polymerases (Fischhaber and Friedberg,2005).When compared with the replicative polymerases,TLS polymerases have comparatively large active sites to incorporate the base opposite the damaged DNA and low fidelity to ensure progression of synthesis using the damaged template (McCulloch and Kunkel,2008).