The Effect of Si-Doping on the Release of Antibiotic from Hydroxyapatite Coatings

• 作者: Carl Lindahl H?kan Engqvist Maria Str?mme Mirjam Lilja Wei Xia
• 来源期刊: 生物材料与纳米技术(英文)
• 学科: 医学
• 关键词: TITANIUM Dioxide HYDROXYAPATITE CEPHALOTHIN DRUG RELEASE Si-Doping
• 年，卷（期）: 2013,（3）
• 页码范围: 237-241
• 页数: 5页
• 分类号: R73

摘要

Herein, we show that incorporation of ions during biomimetic coating deposition may be utilized to tailor the drug loading capacity of hydroxyapatite (HA) coatings. Pure biomimetic HA (HA-B) and Si-doped equivalents (SiHA-B) where deposited by a biomimetic process onto titanium dioxide covered titanium substrates. The antibiotic Cephalothin was incorporated into the coatings by adsorptive loading and the release was studied in-vitro. SiHA-B coatings exhibited superior drug incorporation capacity compared to pure HA-B coatings, resulting in a drug release profile dominated by an initial 10 min burst effect while a more prolonged 10 hour release was observed from HA-B coatings. The results emphasize the possibility to impact the drug release kinetics from implant coatings by selective doping elements and the use of thin, biomimetic HA-coatings as drug delivery vehicles. Functionalizing metal implants with SiHA-B coatings presents an interesting strategy towards creating synergetic effects through ion- and antibiotic release and, hence, contributing both towards preventing post-surgical infections while at the same time enhancing the bone-bonding ability.