Mice cloned from white adipose tissue-derived cells

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2013,（5）
• 页码范围: 348-350
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/jmcb/mjt019

摘要

Dear Editor, Somatic cells can be reprogrammed into totipotent or pluripotent state by nuclear transfer (NT) or the ‘Yamanaka method'.White adipose tissue (WAT) is a source of readily accessible donor cells that provide virtually unlimited cells for reprogramming.Recently,freshly isolated white adipose tissue-derived cells (ADCs) from humans or mice have been successfully reprogrammed into induced pluripotent stem cells (iPSCs) by ‘Yamanaka factors' (Sun et al.,2009;Sugii et al.,2010).In contrast,cultured mouse ADCs were not feasible donors for NT,most likely due to chromosome instability that might occur during in vitro culture (Qin et al.,2009).Therefore,it remains unknown whether genomic stability sustains in freshly isolated mouse ADCs that can be used as donors for NT.