Ras and macropinocytosis:trick and treat

• 作者: Boudewijn M T Burgering Fried J T Zwartkruis
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（8）
• 所属期刊栏目: RESEARCH HIGHLIGHTS
• 页码范围: 982-983
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2013.79

摘要

Oncogene-driven adaptation of metabolism during tumorigenesis includes steps that stimulate the uptake of nutrients,especially glucose and glutamine,to sustain cell growth and proliferation.Macropinocytosis,a clathrin-and caveolin-independent endocytotic process that had previously been linked to the action of oncogenic Ras and Src,is now shown to contribute to amino acid uptake via enhanced delivery of extracellular proteins to lysosomes. Tumorigenesis is a multistep process in which cells acquire the capacity to proliferate in an unrestrained fashion and ultimately to metastasize.