Retinoblastoma: concerning its initiation and treatment

• 作者: Chang Luo Ying-Ping Deng
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: RETINOBLASTOMA RETINOBLASTOMA 1 GENE leukocoria EPIDEMIOLOGY MEDICAL management
• 年，卷（期）: 2013,（3）
• 页码范围: 397-401
• 页数: 5页
• 分类号: R739.7

摘要

Retinoblastoma (RB) is the most common intraocular cancer of infancy and childhood. This cancer is initiated by mutation on RB1, the tumor suppressor gene that is responsible for the regulation of both cell cycle and gnome stability in retinal cells. Patients with a constitutional mutation on RB1 can be inherited. RB occurs approximately 1 in every 15 000-20 000 live births. The worldwide mortality for this cancer is about 5%-11%. However, this rate rises to about 40%-70% in developing countries due to a delay in diagnosis. A wide variety of options are available for the treatment, but often a combination of therapies is adopted to optimize individualized care.