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摘要:
Background: Widespread resistance has been recorded with the use of monotherapy in the management of malaria. In 2000, Ghana initiated the process of using Artemisinin-based combination therapy (ACT) following the World Health Organization’s (WHO) recommendation. Globally and in Ghana, there stands a high risk of development of resistance to the ACTs due to the act of counterfeiting or substandard drugs. In 2009, there was a report that fake Coartem, an ACT had been found in Ghana by the Drug Quality and Information (DQI) Program;this is a serious national problem that needs redress thus the need to conduct this study to check if there are any substandard or counterfeit Artemether/ Lumefantrine tablets on the Ghanaian market. Method: Using Representative sampling method, a total of nine different brands or samples of artemether/lumefantrine tablets were sampled from nine different Pharmacies in Accra. The samples were analyzed using a validated MVHimagePCv8.exe colour software technology. Results: The International Conference on Harmonization (ICH) and United States Pharmacopoeia (USP) recommend that for assay of tablets, the percentage concentration should fall within 80%-120%. After the analysis, seven out of the nine samples passed the test to varying degrees. Two samples (AL-S4 and AL-S6) however failed the test with AL-S4 recording artemether concentration (126.07%) above and Lumefantrine concentration (78.38%) below the recommended figure while AL-S6’s 51.53% failed to meet the minimum allowable concentration for lumefantrine in a tablet. Conclusion: The results presented show that some Artemether/Lumefantrine tablets on the Ghanaian market still have issues with regards to quality or level of active ingredients. There would therefore be the need for further studies to be conducted into these products especially those that failed the test.
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篇名 Quality Assessment of Artemether/Lumefantrine Tablets Sampled from Pharmacies in Accra, Using the MVHimagePCv8.exe Color Software
来源期刊 药理与制药(英文) 学科 医学
关键词 Artemisinin-Based Combination Therapy Resistance COUNTERFEIT or Substandard Drugs
年,卷(期) ylyzyyw_2013,(8) 所属期刊栏目
研究方向 页码范围 567-572
页数 6页 分类号 R73
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研究主题发展历程
节点文献
Artemisinin-Based
Combination
Therapy
Resistance
COUNTERFEIT
or
Substandard
Drugs
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研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
药理与制药(英文)
月刊
2157-9423
武汉市江夏区汤逊湖北路38号光谷总部空间
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444
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0
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