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摘要:
An initial burst is often observed during the release of active pharmaceutical ingredients (APIs) from poly-lactic-coglycolic-acid (PLGA) microparticles (MPs) which have been prepared by the emulsion-solvent evaporation method. Herein, we describe the development of a simple one-step coating method that suppresses the initial burst release process. This new method involves coating the PLGA-MPs with PLGA, with the coating process being performed through the phase separation of PLGA on the surface of PLGA-MPs using the emulsion-solvent evaporation method. Bovine serum albumin (BSA) was encapsulated in the PLGA-MPs as a model API. The coated MPs were spherical in shape with no pores on their smooth surface, whereas the non-coated PLGA-MPs had porous surfaces. An in vitro release study showed that the residual levels of BSA in the coated and non-coated PLGA-MPs after 1 h were about 99% and 16% of the original loads, respectively. The one-step coating method therefore represents a useful method for preparing PLGA-MPs that do not give an initial burst release of proteinaceous APIs.
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篇名 One-Step Preparation of Poly-Lactic-Co-Glycolic-Acid Microparticles to Prevent the Initial Burst Release of Encapsulated Water-Soluble Proteins
来源期刊 药理与制药(英文) 学科 医学
关键词 Poly-Lactic-Co-Glycolic-Acid Microparticle Suppression of INITIAL Burst Release Coating Bovine Serum Albumin
年,卷(期) ylyzyyw_2013,(8) 所属期刊栏目
研究方向 页码范围 578-583
页数 6页 分类号 R73
字数 语种
DOI
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研究主题发展历程
节点文献
Poly-Lactic-Co-Glycolic-Acid
Microparticle
Suppression
of
INITIAL
Burst
Release
Coating
Bovine
Serum
Albumin
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
药理与制药(英文)
月刊
2157-9423
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
444
总下载数(次)
0
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