hESC-derived pancreatic progenitors

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（5）
• 页码范围: 592-594
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2013.20

摘要

Successful derivation of pancreaticprogenitors from human embryonic stem cells (hESCs) in vitro and further differentiation towards functional β cells in vivo may create the possibility of using hESC-derived pancreatic progenitors (PPs),instead of derived β cells,as an alternative transplantable source in β cell replacement therapy.Here we discuss present approaches,as well as future alternatives,in the fields of basic and clinic research on β cell differentiation,derivation and transplantation. Type 1 diabetes is a chronic metabolic disease characterized by the loss of β cells in the pancreas.Patients can benefit from transplantation of islet cells harvested from donor pancreas to restore a functional β cell mass.Since the number of pancreas donors is far too low and cannot satisfy the requirements of most diabetes patients,this has stimulated research worldwide to find altemative and sustainable sources of β cells.