Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy

• 作者: Ali Bülent ankaya Emrullah Beyazyildiz Esra Ergan Faruk ztürk Mehmet Hakan Tirhis Mustafa Alparslan Anayol Pelin Yilmazbas Sevilay Sezer Yasemin zdamar
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: aqueous HUMOR DIABETIC RETINOPATHY TOTAL antioxidant capacity TOTAL OXIDANT status
• 年，卷（期）: 2013,（4）
• 页码范围: 531-536
• 页数: 6页
• 分类号: R587.2

摘要

AIM:To measure changes of total oxidant status(TOS)and total antioxidant capacity(TAC) of aqueous humor(AH) in diabetic retinopathy(DR) patients,and to determine if there were any differences in TOS and TAC of AH in diabetic patients without retinopathy compared with non-diabetic patients.·METHODS:One hundred and three eyes of 103patients who were enrolled for cataract surgery were included in this study.Patients were grouped according to presence of diabetes and stage of DR.Prior to cataract surgery,0.1mL to 0.2mL of AH was aspirated and analyzed for TAC and TOS level using a colorimetric method.·RESULTS:TOS levels were highest among proliferative diabetic retinopathy(PDR) patients and lowest in patients with only cataracts.Results were statistically significant between all groups(P 【0.05).Whereas result between diabetic without retinopathy patients and non-proliferative diabetic retinopathy(NPDR) patients was not statistically significant(P =0.757).TAC levels were highest in patients with only cataract and lowest among PDR patients and results were statistically significant between all groups(P 【0.05).·CONCLUSION:Aqueous humor TAC levels are low in diabetic patients and reduced further in DR patients,TOS levels are increased in diabetic patients and this is exacerbated in DR patients.