Interference cancellation system (ICS) for 3GPP/LTE system is the broadband cancellation system, which receives forward signal through the donor antenna. We proposed new algorithm of received signal with pilot and non-pilot design. Although repeater design needs our project, so in this paper we discuss about interference cancellation algorithm for 2x2 MIMO systems without pilot in LTE. First explain the general principle structure of 3GPP/LTE, next determine our new design and algorithm. Finally, we simulated our mathematic extraction of proposed new algorithm on MATLAB.