在虹和对待的医学上和未经治疗的主要开的角度绿内障病人的 trabecular 网状组织的 Apoptosis

• 作者: Emine Esra Karaca Ipek Isik Gonul Merih Onol Murat Hasanreisoglu Zeynep Aktas
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: GLAUCOMA TRABECULAR MESHWORK APOPTOSIS
• 年，卷（期）: 2013,（6）
• 页码范围: 827-830
• 页数: 4页
• 分类号: R775.2

摘要

AIM:To compare the trabecular meshwork(TM)and iris apoptosis of treated and untreated primary open angle glaucoma(POAG)patients.METHODS:Eight treatment-naive,newly diagnosed(group 1)and 11 medlcaiy treated(group 2)patients with POAG were included in the study.Each patient underwent a limbus-based trabeculectomy.The TM and peripheral iris specimens were dissected out and were snap-frozen in liquid nitrogen and stored at-80t until they were assayed.Apoptosis in each group was assesed by TUNEL method.RESULTS:The mean patient age was 60.6±5.8 years(53-68 years)vs 58.9±8.9 years(47-70 years)in group 1and group 2(P=0.859).The mean treatment time in group 2 was 22.2±7.3 months(12-34 months).Apoptotic indexes in TM and iris were significantly higher in POAG patients using medication(group 2)compared to treatment-naive POAG patients(group 1)(P=0.004,0.015;respectively).CONCLUSION:Long term administration of topical antiglaucoma medications causes additional toxic effects on TM.