补充因素 B 多型性(rs641153 ) 和到年龄相关的有斑点的退化的危险性: 从出版研究的证据

• 作者: Mao-Nian Zhang Xin Wang Ying Zhang
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: COMPLEMENT factor B rs641153 AGE-RELATED MACULAR DEGENERATION meta-analysis
• 年，卷（期）: 2013,（6）
• 页码范围: 861-867
• 页数: 7页
• 分类号: R774.5

摘要

AIM:To determine whether single nucleotide polymorphism(SNP)rs641153 is associated with the risk of age-related macular degeneration(AMD),we performed a systematic meta-analysis of 15 eligible studies.SNP in the complement factor B(CFB)gene is considered to have significant association with AMD susceptibility,but there is great discrepancy in these results.METHODS:The eligible studies were identified by searching the databases of PubMed,EMBASE,and Web of Science.Odds ratios(ORs)with 95%confidence intervals(CIs)were used to assess the association.All data were analyzed using Stata software.RESULTS:The association between rs641153 and AMD risk was statistically significant under the homozygous model(AA vs GG:OR=0.26,95%CI=0.15-0.45,P_h=0.973,/~2=0.0%,fixed effects),dominant model(AA+GA vsGG:OR=0.49,95%CI=0.40-0.59,P_h=0.004,/~2=56.4%,random effects)and recessive model(AA vs GA+GG:OR=0.30,95%CI=0.17-0.51,R_n=0.983,I~2=0.0%,fixed effects).The same results were also observed in the stratified analyses by ethnicity,source of control and sample size.CONCLUSION:Our meta-analysis suggests that rs641153 in the CFB gene may play a protective role in AMD susceptibility,the late AMD in particular,both in Caucasians and in Asians.