对冒号肿瘤的抗抑郁剂 fluoxetine 和它的潜力

• 作者: Helga Stopper Sergio Britto Garcia Ana Maria Waaga-Gasser Vinicius Kannen
• 来源期刊: 世界胃肠肿瘤学杂志：英文版（电子版）
• 学科: 医学
• 关键词: FLUOXETINE COLON CANCER CANCER therapy Tumor METABOLISM
• 年，卷（期）: 2014,（1）
• 页码范围: 11-21
• 页数: 11页
• 分类号: R735.35

摘要

Colon cancer is one of the most common tumors worldwide,with increasing incidence in developing countries.Patients treated with fluoxetine(FLX) have a reduced incidence of colon cancer,although there still remains great controversy about the nature of its effects.Here we explore the latest achievements related to FLX treatment and colon cancer.Moreover,we discuss new ideas about the mechanisms of the effects of FLX treatment in colon cancer.This leads to the hypothesis of FLX arresting colon tumor cells at the at G1 cell-cycle phase through a control of the tumor-related energy generation machinery.We believe that the potential of FLX to act against tumor metabolism warrants further investigation.