Immunolocalization of Ephexin-1 in the Developing Canine Cerebellum

• 作者: Han Yong Kim Hyun Sik Park In Youb Chang Sang Pil Yoon
• 来源期刊: 神经系统科学与医药(英文)
• 学科: 医学
• 关键词: Ephexin-1 CEREBELLUM PURKINJE Cells Development Dog
• 年，卷（期）: 2014,（1）
• 页码范围: 9-14
• 页数: 6页
• 分类号: R73

摘要

Ephexin-1 functions as guanine nucleotide exchange factors for the Rho-type GTPases which have important roles in neuronal development including axon guidance, migration, morphogenesis, and plasticity of neurons. As little is known about ephexin-1 in the cerebellum, we investigated the immunolocalization of ephexin-1 in the developing canine cerebellum. While the cellular maturation was followed by the temporal pattern, the calbindin D-28k and ephexin-1 immunoreactivities gradually increased in developing canine cerebellum. When compared to the calbindin D-28k immunoreactivities, belated ephexin-1 immunolocalization was observed in the Purkinje cells which aligned a single layer during cerebellar development. These results suggest that ephexin-1 might play an important role in the development of the Purkinje cells during the first two postnatal weeks based on its immunolocalization in the present study.