Aromatic Bromination in Concentrated Nitric Acid

• 作者: Alexander M. Andrievsky Mikhail K. Grachev Mikhail V. Gorelik Vera I. Lomzakova
• 来源期刊: 合成理论与应用(英文)
• 学科: 化学
• 关键词: BROMINATION NITRATION AROMATIC COMPOUNDS 3-Bromo-4-chloronitrobenzene 5 Bromoisophthalic ACID 2 3 5 6-Tetrabromoterephthalic ACID 4 6 Tetrabromophthalic ANHYDRIDE
• 年，卷（期）: 2014,（2）
• 页码范围: 15-20
• 页数: 6页
• 分类号: O6

摘要

Action of bromine in concentrated nitric acid allows carrying out mono- and polybromination of moderately deactivated aromatic compounds. 4-Chloronitrobenzene and isophthalic acid turnes into 3-bromo-4-chloronitrobenzene and 5-bromoisophthalic acid at reaction with bromine in concentrated nitric acid at 20°C whereas in absence of bromine in the same conditions 4-chloro-1, 3-dinitrobenzene and 5-nitroisophthalic acid are formed accordingly. Presence of bromine in concentrated nitric acid changes nitrating capacity to brominating one. Terephthalic acid and phthalic anhydride at heating with bromine in concentrated nitric acid can be transformed to appropriating tetrabromo substituted compounds.