Gender medicine and psoriasis

• 作者: Delia Colombo Gilberto Bellia Gino A Vena Nicoletta Cassano
• 来源期刊: 世界皮肤病学杂志
• 学科: 医学
• 关键词: PSORIASIS Psoriatic ARTHRITIS GENDER MEDICINE SEX differences Epidemiology Risk factors Clinical aspects COMORBIDITIES Quality of life Therapeutic management
• 年，卷（期）: 2014,（3）
• 页码范围: 36-44
• 页数: 9页
• 分类号: R

摘要

The study of specific differences between women and men is arousing huge interests in various fields of medicine,including dermatology.The available data on gender medicine applied to common skin diseases are unfortunately still scanty.Psoriasis is a chronic immunemediated skin disease which affects 1%-3%of most populations worldwide and can involve also the joints and entheses.The pathogenesis of the disease is very complex,resulting from the interaction between genetic predisposition and several environmental triggers.The pathogenic role of sex hormones has also been hypothesized.The analysis of gender-specific differences in psoriasis seems to suggest some interesting findings,such as an earlier age of disease onset in females,a higher probability of severe disease in men,or different tendencies in care utilization,adherence to treatment,development of psychological distress,and coping strategies.Moreover,sex-related differences have been recently described in some epidemiological and clinical features among patients with psoriatic arthritis.The objective of this article is to review briefly the available evidence regarding gender differences in various aspects of psoriasis,such as epidemiology,genetics,risk factors,associated conditions,quality of life,clinical and therapeutic aspects.