Pathogenesis and diagnosis of contact dermatitis:Applications of reflectance confocal microscopy

• 作者: Ernesto González Jorge A Suárez-Pérez Ricardo Bosch Salvador González
• 来源期刊: 世界皮肤病学杂志
• 学科: 医学
• 关键词: DERMATITIS ALLERGIC contact ECZEMA ETIOLOGY DIAGNOSIS
• 年，卷（期）: sjpfbxzz_2014,（3）
• 页码范围: 45-49
• 页数: 5页
• 分类号: R

摘要

Contact dermatitis(CD)is the most common professional skin disease,with frequencies ranging from 24 to 170 every 100000 individuals.Approximately 20%of the United States population suffers from CD.CD can be classified according to its origin and severity.ICD stands for irritant CD,whereas ACD means allergic CD.Their clinical presentation includes acute,sub-acute and chronic eczema.Despite their different origin,ICD and ACD often present similar clinical and histologic findings.The current gold standard for diagnosis is patchtesting.However,patch-testing is being questioned in terms of validity and reproducibility,as it relies heavily on the skill of the observer.Real-time reflectance confocal microscopy is a non-invasive imaging technique that bears strong promise for the study of CD,and it enables the evaluation of cellular and subcellular changes over time with similar resolution compared to that of conventional histology.