Animal models of ex vivo lung perfusion as a platform for transplantation research

• 作者: Bryan A Whitson Christopher Bobba Don Hayes Jr Kevin Nelson Samir Ghadiali Sylvester M Black
• 来源期刊: 世界实验医学杂志
• 学科: 医学
• 关键词: EX VIVO LUNG PERFUSION Transplantation Rat Porcine Small ANIMAL Large ANIMAL Model EX VIVO LUNG PERFUSION
• 年，卷（期）: sjsyyxzz,（2）
• 页码范围: 7-15
• 页数: 9页
• 分类号: R

摘要

Ex vivo lung perfusion(EVLP)is a powerful experimental model for isolated lung research.EVLP allows for the lungs to be manipulated and characterized in an external environment so that the effect of specific ventilation/perfusion variables can be studied independent of other confounding physiologic contributions.At the same time,EVLP allows for normal organ level function and real-time monitoring of pulmonary physiology and mechanics.As a result,this technique provides unique advantages over in vivo and in vitro models.Small and large animal models of EVLP have been developed and each of these models has their strengths and weaknesses.In this manuscript,we provide insight into the relative strengths of each model and describe how the development of advanced EVLP protocols is leading to a novel experimental platform that can be used to answer critical questions in pulmonary physiology and transplant medicine.