Degradation of nucleic acids and nucleotides in several conditions with perspectives of retrieval: A review

• 作者: Agustina Ortiz Soriano Iván Vera Romero José Martínez Reyes Lenin Ejecatl Medina Orozco Melitón Estrada Jaramillo
• 来源期刊: 生命科学与技术进展(英文)
• 学科: 医学
• 关键词: DNA Chemical DEGRADATION
• 年，卷（期）: 2014,（1）
• 页码范围: 36-39
• 页数: 4页
• 分类号: R73

摘要

Deoxyribonucleic acid (DNA) or oligonucleotides, can be modified in several ways as chemical degradation by electrophilic reaction, attack of radicals, hydrolytic deamination or oxidative damage caused by ionizing radiation. This work discussed these degradation mechanisms, determining the effects on these biomolecules. The actual knowledge about DNA damages only permits partial enzymatic repair treatments.