Microbubble technology is now available in a wide range of industrial fields. The liquid containing microbubbles possesses a large number of air-liquid interfaces, and also generates radicals during bubble collapse. Here, we synthesized ZnO powder to explore the potential of microbubbles as starting materials for the formation of crystalline micro- or nanoparticles. The bubbles facilitated the growth of ZnO microneedles in high yields, and enhanced the reaction by radicals generated on bubble collapsing.