Prognostic Role of miR-205 in Early-Stage (T1N0) Non-Small Cell Lung Cancer

• 作者: Adele Servadio Alfredo Mussi Alice Cocco Franca Melfi Gabriella Fontanini Greta Alì Laura Boldrini Marco Lucchi Mirella Giordano Pietro Bertoglio
• 来源期刊: 肺癌(英文)
• 学科: 医学
• 关键词: NON-SMALL Cell LUNG Cancer MIR-21 let-7g miR-205 Prognosis
• 年，卷（期）: 2014,（2）
• 页码范围: 45-51
• 页数: 7页
• 分类号: R73

摘要

Background: Published data have shown that microRNAs (miRNAs) could play a potential role as diagnostic and prognostic indicators in cancers. Data for the predictive value of miRNA let-7, miR-21, and miR-205 are inconclusive. The aim of the present analysis was therefore to evaluate the expression and the prognostic role of the above mentioned miRNAs?in early-stage?(T1N0) NSCLC patients. Methods: Quantification of let-7g, miR-21, and miR-205 expression was carried out into 105 early-stage NSCLC by quantitative Real Time-PCR (qRT-PCR).?Results: a significant association between the low miR-205 expression and ADC histotype (p??0.0001) compared to SCC?was found;moreover, survival analysis showed thattumors with a high?miR-205 expression had a significantly shorter mean PFS and OS compared to the patients with a low expression of this miRNA (p = 0.02 and p = 0.03, respectively). No other statistically significant correlations were observed between the analysed miRNAs and the main clinico-pathological characteristics of the NSCLC patients. Conclusion: The results indicated that miR-205 could represent a useful marker in the prognostic management of the early-stage (T1N0) NSCLC patients.