Molecular Characterization and mRNA Expression of Cytochrome P450 1A1 and Cytochrome P450 3A in Liver of Kafue Lechwe (<i>Kobus leche kafuensis</i>) as Potential Biomarkers of Pollution of the Kafue River Basin, Zambia

• 作者: Ethel M’kandawire Girja Pandey Kaampwe Muzandu Martin Simuunza Mayumi Ishizuka Michelo Syakalima Shouta M. M. Nakayama Yoshinori Ikenaka Yusuke K. Kawai
• 来源期刊: 工程(英文)(1947-3931)
• 学科: 医学
• 关键词: Lochnivar GAME MANAGEMENT Area Blue Lagoon GAME MANAGEMENT Area Pestcides/Herbicides BIOMONITORING Phylogenetic Relationships Real-Time RT-PCR
• 年，卷（期）: gc-eng,（2）
• 页码范围: 51-58
• 页数: 8页
• 分类号: R73

摘要

The aim of this study was to characterize CYP1A1 and CYP3A in liver of the Kafue lechwe from Lochnivar and Blue Lagoon GMAs and to determine their mRNA expression levels as potential biomarkers of pollution. Increasing attention is paid to the problem of pesticide pollution by people. Risk assessment of pesticide should not be only based on the chemical analysis of environmental samples, since this method could not truly distinguish whether the pesticide was harmful to environment. Thus, biological assessment should be established.