Discovering the Hippo pathway protein-protein interactome

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（2）
• 页码范围: 137-138
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2014.6

摘要

The Hippo pathway is a signal transduction pathway that regulates organ growth,stem cell biology,regeneration and cancer.Three recent proteomic studies with Hippo pathway components uncovered extensive networks of interacting proteins revealing novel connections to cellcell junctions,regulation by vesicle trafficking,and phosphorylationdependent remodeling of the interactome,and provide a rich landscape of novel interactors ripe for mechanistic studies.