Absence of Expression of OCT-2 in Gastric Cancer Cells

• 作者: Ana Rute Fernandes Henrique Bicha Castelo José Crespo Mendes de Almeida José Paulo Freire Maria Concei??o Crujo Maria Emilia Oliveira
• 来源期刊: 美国分子生物学期刊(英文)
• 学科: 医学
• 关键词: GASTRIC Cancer LYMPH NODE METASTASIS OCT-2 Stem Cells
• 年，卷（期）: 2014,（3）
• 页码范围: 129-133
• 页数: 5页
• 分类号: R73

摘要

OCT-2, a member of the POU homeodomain family of transcription factors, has been implicated in gastric cancer lymph node metastasis on a single publication so far. Other members of the same family of transcription factors were found to have a role in intestinal metaplasia and gastric cancer (OCT-1) and in trophectoderm differentiation of embryonic stem cells (OCT3/4) via modulation ofCDX2. These findings prompted us to evaluate whether OCT-2 could in fact have a role in gastric oncogenesis and lymph node metastasis in human gastric cancer, designing an immunohistochemistry study of the putative expression of OCT-2 on human gastric cancer tissue of 69 surgical archival specimens of intestinal and diffuse type. We could not find expression of OCT-2 on any of our cancer tissues, metaplasia or normal gastric mucosa despite the expression of OCT-2 on tonsil lymphatic cells (tissue test) and normal lymph nodes. We concluded that, based on immunohistochemistry, OCT-2 does not have a role in gastric oncogenesis nor does have any relationship with lymph node metastasis in gastric cancer.