Association of four GSTs gene polymorphisms with Parkinson disease: A meta-analysis

• 作者: Cheng Chen Dongjun Dai Guanghui Pan Hanlin Zhou Hui Wang Jinfeng Li Jun Pan Leiting Xu Limin Xu Lingyan Wang Meng Ye Ping Ru Qingqing Ma Shengqian Zhu Shiwei Duan Xingyu Zhou Yuelong Lv Yunliang Wang
• 来源期刊: 生命科学与技术进展(英文)
• 学科: 医学
• 关键词: Parkinson GSTM1 Deletion Polymorphism META-ANALYSIS Europeans GSTT1 GSTP1
• 年，卷（期）: 2014,（2）
• 页码范围: 100-107
• 页数: 8页
• 分类号: R73

摘要

Parkinson disease (PD) is a neurological disorder with huge destruction to human body, which affects approximately 2% of the population aged 65 years or older. As antioxidants in the stress defence systems, glutathione S-transferases (GSTs) are dimeric cytosolic enzymes with an important role in the pathogenesis of PD. The aim of this study was to evaluate the association between the polymorphisms of GST genes and PD. Meta-analyses were conducted from 17 studies (38 stages) among 3419 cases and 5686 controls between four polymorphisms (GSTT1 deletion polymorphism;GSTM1 deletion polymorphism;GSTP1-104: rs1695;GSTP1-114: rs1799811) and PD. There is no significant association between the four GST gene variants and PD. A further subgroup study by ethnicity observed a risky role of GSTM1 deletion polymorphism with PD in Europeans (p = 0.013, OR = 1.126, 95% CI = 1.025-1.236), and a protective role of GSTM1 deletion polymorphism with PD in Latin Americans (p = 0.032, OR = 0.750, 95% CI = 0.577-0.975). Our meta-analysis suggested that GSTM1 deletion polymorphism increased the risk of PD in Europeans, but reduced the risk of PD in Latin Americans. Future large-scale studies might be needed to confirm the ethnic difference of GSTM1 deletion polymorphism, and to check whether there was significant association of PD for other GST genetic polymorphisms.