Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

• 作者: Craig A Friesen Jennifer M Colombo Jennifer V Schurman John M Rosen Jose T Cocjin
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: MOTILITY VISCERAL HYPERSENSITIVITY Functional DYSPEPSIA
• 年，卷（期）: 2014,（3）
• 页码范围: 122-138
• 页数: 17页
• 分类号: R725.7

摘要

Functional gastrointestinal disorders(FGID) are common clinical syndromes diagnosed in the absence of biochemical,structural,or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age,geography,and culture. Etiology of abdominal pain associated FGIDs,including functional dyspepsia(FD),remains incompletely understood,but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD,with focus on pediatric data when available,and provides a summary of potential therapeutic targets.