Synthesis of New Fluorine/Phosphorus Substituted 6-(2’-Amino Phenyl)-3-Thioxo-1,2,4-Triazin-5(2H, 4H)One and Their Related Alkylated Systems as Molluscicidal Agent as against the Snails Responsible for Bilharziasis Diseases

• 作者: Abeer N. Al-Romaizan Mohammed S. T. Makki Reda M. Abdel-Rahman
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: FLUORINE PHOSPHORUS Sulfur-1 2 4-Triazine Characteristic Properties Molluscicidal Activity
• 年，卷（期）: yjhxgjqkyw,（2）
• 页码范围: 154-168
• 页数: 15页
• 分类号: O6

摘要

New fluorine substituted 6-(5’-fluoro-2’-triphenylphosphiniminophenyl) 3-thioxo-1,2,4-triazin-5 (2H, 4H) one (2) was obtained via Wittig’s reaction of the corresponding 6-(5’-fluoro-2’-amino-phenyl)-3-thioxo-1,2,4-triazinone (1). Behavior of compound 2 towards alkylating agents and/or oxidizing agents was studied were, N-hydroxyl (3), Mannich base (4,5), S-alkyl (6,7,8) and thiazolo [3,2-b][1,2,4] triazinones (10-14) and or 3-disulfide (18), 3-sulfonic acid 19 and 1,2,4-triazin-3,5-Dionne (20) derivatives obtained. Structures of the new products are established by elemental and spectral data. The new targets obtained screened as Molluscicidalagents against Biomophlaria Alexandrina snails responsible for Bilharziasis diseases, in compare with Baylucide as standard drug.