Multicenter Analysis of mFOLFOX6 with Oxaliplatin Stop-and-Go Strategy Using Oral Uracil-Tegafur with Leucovorin for Unresectable Colorectal Cancer in Elderly Patients

• 作者: Akiyoshi Kanazawa Eiji Hira Hiroshi Takeda Kuniyuki Katano Masahide Ikeguchi Shinichi Sugimoto Tetsu Yamamoto Yoshitoshi Sato Yoshitsugu Tajima Yutaka Yamashiro
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: Colorectal Cancer OXALIPLATIN Uracil-Tegafur (UFT) LEUCOVORIN Elderly Patient Stop-and-Go
• 年，卷（期）: 2014,（2）
• 页码范围: 147-154
• 页数: 8页
• 分类号: R73

摘要

Background: This study evaluated the tolerability and efficacy of intermittent oxaliplatin treatment based on mFOLFOX6 using oral uracil-tegafur(UFT) and leucovorin(LV) maintenance therapy in the treatment of elderly patients with advanced colorectal cancer. Methods: Ten non-elderly patients (70 years) with advanced/recurrent colorectal cancer were enrolled in this prospective, multicenter cooperative group clinical trial. The mFOLFOX6 regimen was administered for eight cycles with maintenance therapy with oral UFT/LV treatment until progression. In cases with disease progression, mFOLFOX6 was reintroduced. Results: Grade 2 peripheral neuropathy was noted in 30.0% and 25.0% of the elderly and non-elderly patients, respectively. The observed time to treatment failure (TTF) was 6.3 months in the elderly patients and 6.4 months in the non-elderly patients. The disease control rate was 83.3% in each group. Conclusion: Our new stop-and-go strategy using oral UFT/LV is well-tolerated and effective even in elderly patients.