Molecular mechanism of inflammatory pain

• 作者: Chih-Cheng Chen Wei-Hsin Sun Yeu-Shiuan Su
• 来源期刊: 世界麻醉学杂志
• 学科: 医学
• 关键词: Acid-sensing ION CHANNEL ACIDOSIS G-protein-coupled RECEPTOR Inflammation Proton-sensing ION CHANNEL Transient RECEPTOR potential V1
• 年，卷（期）: 2014,（1）
• 页码范围: 71-81
• 页数: 11页
• 分类号: R

摘要

Chronic inflammatory pain resulting from arthritis,nerve injury and tumor growth is a serious public health issue.One of the major challenges in chronic inflammatory pain research is to develop new pharmacologic treatments with long-term efficacy and few side effects.The mediators released from inflamed sites induce complex changes in peripheral and central processing by directly acting on transducer receptors located on primary sensory neurons to transmit pain signals or indirectly modulating pain signals by activating receptors coupled with G-proteins and second messengers.High local proton concentration(acidosis)is thought to be a decisive factor in inflammatory pain and other mediators such as prostaglandin,bradykinin,and serotonin enhance proton-induced pain.Proton-sensing ion channels[transient receptor potential V1(TRPV1)and the acid-sensing ion channel(ASIC)family]are major receptors for direct excitation of nociceptive sensory neurons in response to acidosis or inflammation.G-protein-coupled receptors activated by prostaglandin,bradykinin,serotonin,and proton modulate functions of TRPV1,ASICs or other ion channels,thus leading to inflammation-or acidosis-linked hyperalgesia.Although detailed mechanisms remain unsolved,clearly different types of pain or hyperalgesia could be due to complex interactions between a distinct subset of inflammatory mediator receptors expressed in a subset of nociceptors.This review describes new directions for the development of novel therapeutic treatments in pain.